Formulators do not buy claims, they buy numbers with a method attached. This page consolidates the published performance, safety and readiness data for the PureSurf portfolio. Every figure names the grade, the standard it was measured against, the test conditions and the maturity of the underlying report. Where a report is still a draft, we say so rather than publishing the more favourable number.
- Grades
- NEXOVANT F Pro, F Eco, RHEOSYL, SYLVAXIS
- CMC, F Pro
- 33 mg/L (independently measured)
- CLP classification
- Stated per grade, see table
- Batch scale
- 50 kg per batch (F Pro)
How to read the data status
We label the maturity of every number on this page. A supplier who does not is asking you to take a formulation risk on their behalf.
- Signed GLP report, study director and quality assurance sign-off complete.
- Study complete, report not yet signed. Figures are preliminary.
- Measured by an independent laboratory or industrial partner.
- PureSurf in-house measurement, non-GLP.
- Early-stage indication, not a specification.
- Classification, dossier or authorisation status rather than a measured value.
- Not released yet. Request the current value from the technical team.
Chemical identity
Both NEXOVANT grades share the same furan-based amine-N-oxide chemistry and differ in the length of the alkyl ether chain. The physico-chemical characterisation of F Eco is still being completed, so several cells are marked as open rather than estimated.
Internal
| NEXOVANT F Pro | NEXOVANT F Eco | |
|---|---|---|
| Chemical name | 5-(N,N-Dimethylaminomethyl)-2-dodecyloxymethylfuran N-oxide | 5-(N,N-Dimethylaminomethyl)-2-decyloxymethylfuran N-oxide |
| CAS No. | 3123068-27-6 | 3123068-18-5 |
| Molecular formula / weight | C20H37NO3 / 339.52 g/mol | C18H33NO3 / 311.47 g/mol |
| Purity | >99 % by NMR and HPLC-UV (Certificate of Analysis, batch STS600) | >99 % as stated in study documentation; batch CoA [TBC] |
| Appearance | White to off-white powder, odourless, hygroscopic | White to off-white powder, odourless |
| Supplied as | Approx. 28 to 30 % aqueous solution (also available as solid) | [TBC] |
| Melting point | 81 °C | 80 °C |
| pH (as supplied solution) | 6.6 to 7.0 | [TBC] |
| Water solubility (25 °C) | 287 to 333 g/L | [TBC] |
| Kinematic viscosity | 2991.5 mm²/s at 28.8 w% in water | [TBC] |
| Density | 0.995 g/cm³ at 28.8 w% in water | [TBC] |
| log Kow | 5.53 (calculated, KOWWIN v1.67) | [TBC] |
| Vapour pressure | 5.84×10⁻⁹ Pa (calculated, MPBPWIN v1.44) | [TBC] |
| Flammability | Non-flammable, not explosive | [TBC] |
| SDS version | v1.1, effective 07.07.2026 | v1.0, effective 03.06.2026 |
| TRL / batch scale | TRL 6 / 50 kg per batch | TRL 5 / 1 kg per batch |
Cells marked [TBC] are open items in the F Eco characterisation programme. Request the current value for your grade through the contact form rather than working from an estimate.
NEXOVANT: surface-active performance
Amine-oxide performance is pH-sensitive and interfacial performance is oil-phase specific, so both are reported with their conditions. Where an independent measurement differs from our in-house value, both are published.
| CMC, F ProThird-party | 33 mg/L measured independently at BASF SE, test pH [TBC] · 80 to 80.7 mg/L in-house at pH 12. Both are published because they differ. Amine-oxide CMC is strongly pH-dependent, so the test pH belongs with the figure. |
|---|---|
| CMC, F EcoInternal | 479 mg/L |
| CMC, benchmarkThird-party | C12 to C14 dimethylamine oxide: 73 mg/L (BASF, same test series) · lauryl amine oxide: 1,019 mg/L · DDAO: 367 mg/L (in-house, pH 12) |
| Interfacial tension, F Pro (10 min, measured at BASF)Third-party | Water / olive oil: 0.69 mN/m against 5.52 mN/m for the C12 to C14 amine oxide benchmark, 8× lower. Water / hexadecane: 2.27 mN/m against 1.80 mN/m for the benchmark. Interfacial performance is oil-phase dependent; we publish both. |
| Surface tension, F Pro (EN 14370, 1.0 g/L)Third-party | 33.27 mN/m (BASF, independent) · 31.4 mN/m (in-house). Benchmark C12 to C14 amine oxide: 30.9 mN/m. |
NEXOVANT: aquatic ecotoxicity
Aquatic hazard classification rests on OECD 201, 202 and 203, the algae, crustacea and fish endpoints regulators use. Those are the methods reported here, benchmarked against a conventional lauryl amine oxide.
| Aquatic toxicity, algae (OECD 201, 72 h, Raphidocelis subcapitata)GLP, in finalisation | Registered values: F Eco EC50 11.9 mg/L · F Pro EC50 1.49 mg/L · lauryl amine oxide benchmark EC50 0.47 mg/L |
|---|---|
| Aquatic toxicity, Daphnia magna (OECD 202, 48 h)GLP, in finalisation | Registered values: F Eco EC50 42.9 mg/L · F Pro EC50 >5 mg/L · lauryl amine oxide benchmark EC50 2.4 mg/L |
| CLP aquatic classificationGLP, in finalisation | F Pro: Aquatic Acute 2 (H401), per SDS v1.1 · F Eco: no aquatic hazard classification on SDS v1.0, internal assessment indicates Category 3, to be confirmed on registration · lauryl amine oxide benchmark: Category 1 |
| Acute fish toxicity (OECD 203)GLP, in finalisation | Study planned for 2027. |
Status of these figures. The values above are those carried in the current safety data sheets. The underlying OECD 201 and 202 study reports are not yet finalised, and for F Pro the draft reports indicate lower EC50 values, that is, higher toxicity, than the safety data sheet currently states, on a measured-concentration basis. One aquatic-toxicity retest is scheduled as part of our REACH programme. We are therefore not publishing a toxicity-advantage multiplier for F Pro until the reports are signed. If you need this endpoint for your own dossier or classification work, request the underlying reports rather than citing this page.
NEXOVANT: biodegradation
The two grades have different biodegradation data and are reported separately. Different OECD 301 methods can give different results for the same substance, so the method is always named alongside the figure.
| Biodegradation, F EcoFinal GLP | 74.7 % ThCO2 in 28 days, OECD 301B (CO2 evolution), GLP, meets the 60 % ready-biodegradability criterion. Figure as stated in the F Eco safety data sheet; the full study report is issued with the data package. |
|---|---|
| Biodegradation, F ProGLP, in finalisation | Under final assessment: 78.9 % ThOD (ammonium basis) / 73.6 % ThOD (nitrate basis) in 28 days by OECD 301F (manometric respirometry), report pending finalisation. An earlier OECD 301B CO2-evolution study on the same substance reached 47.4 % ThCO2 in 28 days, below the 60 % ready-biodegradability threshold. We will publish the final classification when the report is signed. |
Under the EU Detergents Regulation a surfactant is considered biodegradable at 60 % or more ultimate biodegradation within 28 days, and the 10-day window used in the OECD definition of ready biodegradability is not applied. Ready biodegradability under OECD 301 is therefore the stricter of the two criteria.
NEXOVANT: safety and CLP classification
The two grades carry materially different human-health classifications. Both are handled as hazardous raw materials with appropriate personal protective equipment, like the conventional amine oxides they replace.
| CLP classification, F ProRegulatory status | Eye Dam. 1 (H318) · Aquatic Acute 2 (H401) · Signal word: Danger. Per SDS v1.1, effective 07.07.2026. |
|---|---|
| CLP classification, F EcoRegulatory status | Skin Corr. 1B/1C (H314) · Skin Sens. 1 (H317) · Eye Dam. 1 (H318) · Signal word: Danger. Per SDS v1.0, effective 03.06.2026. No aquatic hazard classification is assigned on that sheet. |
| Skin corrosion (OECD 431, RHE)GLP, in finalisation | F Pro: not corrosive · F Eco: corrosive, Cat. 1B/1C (tested as 35 % aqueous solution). |
| Skin irritation (OECD 439, EpiDerm)GLP, in finalisation | F Pro: study returned a positive (irritant) result. This endpoint is not currently reflected on the F Pro safety data sheet and is under review, see the note below. F Eco: not tested by this method. |
| Skin sensitisation (OECD 442C DPRA / 442D KeratinoSens)GLP, in finalisation | F Pro: low reactivity in DPRA, borderline in KeratinoSens · F Eco: low reactivity in DPRA but Nrf2 activation in KeratinoSens, classified as sensitising, Cat. 1. Both results are published because they diverge. |
| Serious eye damage (OECD 492B, SkinEthic HCE)GLP, in finalisation | Both grades: Cat. 1. |
| Mutagenicity (OECD 471, Ames)Final GLP | Both grades: not mutagenic, in S. typhimurium TA98, TA100, TA102, TA1535, TA1537, with and without S9. Final signed reports. |
| PBT / vPvBRegulatory status | Not classified as PBT or vPvB in either safety data sheet. The formal REACH PBT/vPvB assessment is scheduled for 2027 and is not yet complete. |
Two disclosures. First, the OECD 439 skin-irritation result for F Pro is not yet carried on that grade’s safety data sheet; we are having the classification reviewed and will reissue the sheet if it changes. Handle F Pro as a potential skin irritant in the meantime. Second, F Pro’s safety data sheet moved from v1.0 (03.06.2026) to v1.1 (07.07.2026), and both the eye classification and the aquatic ecotoxicity values changed between the two versions. Always work from the current sheet.
Independently measured
NEXOVANT L13 and F Pro were benchmarked against a commercial C12 to C14 dimethylamine oxide by the surfactant department of BASF SE in Ludwigshafen, within the EIC Transition project. The table below is as measured by BASF, including the parameters where our material does not lead.
Third-party
| Parameter (method) | NEXOVANT L13 | NEXOVANT F Pro | C12 to C14 amine oxide |
|---|---|---|---|
| Solubility, 5 % in water | clear | clear, yellowish | clear |
| pH, 5 % in water (EN 1262) | 10.45 | 2.2 | 7.9 |
| Cloud point, 1 % in water (EN 1890 A) | 53 °C | >100 °C | >100 °C |
| Cloud point, 1 % in 5 % NaCl (EN 1890 B) | not determined | >100 °C | >100 °C |
| Foaming capacity, 2 g/L (EN 12728) | 510 mL | 800 mL | 715 mL |
| Drainage | 140 mL | 70 mL | not determined |
| Surface tension, 1.0 g/L (EN 14370) | 31.76 mN/m | 33.27 mN/m | 30.9 mN/m |
| CMC | 6 mg/L | 33 mg/L | 73 mg/L |
| Interfacial tension, water / olive oil, 10 min | 6.54 mN/m | 0.69 mN/m | 5.52 mN/m |
| Interfacial tension, water / hexadecane, 10 min | 0.33 mN/m | 2.27 mN/m | 1.80 mN/m |
The interfacial-tension rows are reported without a standard because the source data does not name one. EN 14370 applies to the surface-tension row only.
RHEOSYL: bio-based gelator and rheology modifier
RHEOSYL builds viscosity without conventional thickening additives. All figures come from internal, non-GLP screening at gram scale, and no absolute viscosity value is published yet.
| Function | Additive-free gelator and rheology modifier |
|---|---|
| Effect observedScreening | Up to approximately 7,000-fold increase in viscosity at 1 wt% in water. Internal screening, non-GLP. No absolute viscosity value is published yet. |
| Biocompatibility screeningScreening | Non-toxic to E. coli and A. fischeri and non-haemolytic at 1 wt%. Internal screening, non-GLP. |
| ReadinessInternal | TRL 4, 15 to 20 g per batch. Laboratory-validated, open for joint formulation trials, not available for volume supply. |
| RegulatoryRegulatory status | No REACH dataset. A biodegradation gate assessment is scheduled for Q3 2026. |
| Feedstock | Renewable lignocellulosic building blocks from the PureSynth platform |
SYLVAXIS: bio-based antimicrobial active
SYLVAXIS is a development-stage active substance, not a finished disinfectant. The distinction matters for how its efficacy data can be read and for what may legally be placed on the EU market.
| Function | Bio-based antimicrobial active, development stage |
|---|---|
| Antimicrobial dataScreening | MIC/MBC activity demonstrated against Gram-positive and Gram-negative strains, including multidrug-resistant ESKAPE isolates. Non-GLP academic cooperation study. |
| Performance in product-level testingScreening | EN 1276 is a suspension test for finished disinfectant products, not for actives. In dirty and protein-rich conditions, efficacy has so far been achieved in combination formulations rather than for the active alone. We do not claim EN 1276 compliance for SYLVAXIS as a standalone active. |
| ReadinessInternal | TRL 4, 50 g per batch. Open for joint formulation development. |
| RegulatoryRegulatory status | Not yet authorised as a biocidal active in the EU. Under Regulation (EU) 528/2012 (BPR), an active substance must be approved for the relevant product type and its supplier listed under Article 95 before a biocidal product may be placed on the EU market. Our target for the BPR pathway is around Q4 2030. SYLVAXIS is available for research and development and joint development only. |
Availability and regulatory timeline
Volume, not production capacity, is the current constraint. The bands below are our current plans, not commitments.
Regulatory status
| Volume band | Available from | Requirement | Status |
|---|---|---|---|
| <1 t/y | Now | No REACH registration required | Active, covers current pilot volumes |
| 1 to 10 t/y | Q4 2026 target | REACH dossier, 1 to 10 t band, PureSurf as lead registrant | Dossier approximately 90 % complete |
| 10 to 100 t/y | Q1 2028 target | Additional studies including 28-day repeated-dose toxicity and reproductive/developmental screening | Planned |
| 100 to 1,000 t/y | Q1 2029 target | Full REACH Annex IX package | Planned |
| SYLVAXIS (biocide) | Around Q4 2030 target | Separate route under the BPR: active-substance approval plus Article 95 supplier listing | Regulatory pathway being defined |
Platform and production status
The PureSynth platform underpins all three product families. The platform was developed in the EIC Transition project PureSurf (Horizon Europe, grant agreement 101058142, EUR 2.48M, 2022 to 2025), coordinated by the University of Graz. Company-stage development is supported by aws Deep Tech PreSeed alongside private financing.
| Compounds screenedInternal | >80 novel compounds |
|---|---|
| Patent familiesTo be confirmed | [TBC: 4 or 5] families covering amine-N-oxide surfactants, sulphonate surfactants, furan-based amine-N-oxides, lignin-derived epoxy resins and amino-acid derivatives. 8+ jurisdictions, 8 named inventors across 3 institutions. First grant: South Africa, December 2024. |
| Freedom to operateThird-party | Independent FTO search (external patent firm, January 2025) across 8 core structure families: 55 families identified, 29 assessed in detail, no blocking third-party rights, 3 active families flagged for monitoring. A supplemental search covering the most recent family is in progress. |
| Scale-upInternal | Laboratory gram scale to 50 kg per batch at a contract manufacturer (F Pro, TRL 6). Next step: 250+ kg per batch. |
| RegulatoryRegulatory status | REACH registration in preparation for the 1 to 10 t/y band, target submission Q4 2026. |
Requesting documentation
Technical data sheets, safety data sheets and certificates of analysis are issued per grade and per batch. Sample quantities for research and development evaluation are supplied on request, together with the supporting study references. Safety data sheets are versioned and we notify customers of record when a classification changes.
Frequently asked questions
Which figures are final GLP results?
Only two data sets on this page are final and signed: the OECD 471 Ames mutagenicity results for both grades, and the OECD 301B biodegradation result for F Eco. Every other GLP figure comes from a study that is complete but whose report is still in finalisation, and is badged accordingly.
Why is there no toxicity-advantage multiplier on this page?
Because the underlying OECD 201 and 202 reports are not signed, and for F Pro the draft reports indicate lower EC50 values than the current safety data sheet states. Publishing a headline ratio off unsigned reports is how suppliers end up retracting numbers. We will publish the final figures instead, including if they are less favourable.
What does TRL 4 mean for RHEOSYL and SYLVAXIS?
Technology Readiness Level 4 means the technology has been validated in a laboratory environment. Both grades are available for joint formulation trials, not for commercial supply at scale. RHEOSYL runs at 15 to 20 g per batch and SYLVAXIS at 50 g per batch.
Can I get a safety data sheet before ordering?
Yes. Safety data sheets and technical data sheets are provided ahead of any sample shipment. F Pro is currently at SDS v1.1, effective 07.07.2026, and F Eco at v1.0, effective 03.06.2026. Request them through the contact form.
Content last reviewed: by Prof. Katalin Barta Weissert
Part of this topic cluster
Bio-based surfactants: the full pillar overviewRelated topics in this cluster
Evidence from our own portfolio: Compare the NEXOVANT, RHEOSYL and SYLVAXIS grade data
